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  4. Recombinant Chicken Protein Wnt-2b (WNT2B)

Recombinant Chicken Protein Wnt-2b (WNT2B)

  • 中文名称：
    鸡WNT2B重组蛋白
  • 货号：
    CSB-YP857835CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    鸡WNT2B重组蛋白
  • 货号：
    CSB-EP857835CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    鸡WNT2B重组蛋白
  • 货号：
    CSB-EP857835CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    鸡WNT2B重组蛋白
  • 货号：
    CSB-BP857835CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    鸡WNT2B重组蛋白
  • 货号：
    CSB-MP857835CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    WNT2B; Protein Wnt-2b
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-385
  • 氨基酸序列
    ECGAFPRTAG AAPRICLPFV LILLALTPRA DSSWWYIGAL GARVICDNIP GLVNKQRQLC QRYPDIMQSV GEGAKEWIRE CQYQFRHHRW NCSTLDRDHT VFGRVMLRSS REAAFVYAIS SAGVVYAITR ACSQGELKAC GCDPLKRGRA KDERGEFDWG GCSDNINYGI RFAKAFVDAK EKKVKDARAL MNLHNNRCGR MAVKRFLKLE CKCHGVSGSC TLRTCWLAMS DFRKTGDYLQ KKYNGAIQVI MNQDGTGFTV ANKNFRKPTK TDLVYFENSP DYCVMDKSAG SLGTAGRVCN KVSRGTDGCE VMCCGRGYDT TRVTRVTKCE CKFHWCCAVR CKECEDTVDV HTCKAPKRAE WLDQT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo.
  • 基因功能参考文献：
    1. Neural crest-derived TGFbs activate both Smad3 and Wnt2b signalling in the adjacent ectoderm to position the lens next to the retina. PMID: 21468017
    2. The anterior optic cup domain, as described in part by Wnt2b expression, is specified through the elaboration of a border within the optic neuroepithelium rather than through interactions with the surrounding environment. PMID: 21179237
    3. Wnt2b expression in the anterior rim of the developing retina is responsible for laminar structure of the retina layer. PMID: 12921742
    4. WNT2B regulates embryonic forelimb development via FGF signaling and WNT/b-catenin signaling PMID: 11290326
    5. Wnt2b maintains the naive state of marginal progenitor cells by attenuating the expression of both proneural and neurogenic genes PMID: 15901663
    6. The expression of Wnt2b or constitutively active beta-catenin inhibited retinal progenitor gene (RPG) expression and the differentiation of retinal neurons. PMID: 16854977

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix. Secreted.
  • 蛋白家族：
    Wnt family
  • 组织特异性：
    Detected at the marginal tip of the developing retina. Expressed in the intermediate and the lateral plate mesoderm in the presumptive chick forelimb region. Expressed in the eye, head ectoderm, prospective forelimb mesenchyme, lung bud, pharyngeal arches
  • 数据库链接：

    KEGG: gga:374243

    STRING: 9031.ENSGALP00000039420

    UniGene: Gga.50310