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  4. Recombinant Chicken Myristoylated alanine-rich C-kinase substrate (MARCKS)

Recombinant Chicken Myristoylated alanine-rich C-kinase substrate (MARCKS)

  • 中文名称：
    鸡MARCKS重组蛋白
  • 货号：
    CSB-YP013493CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    鸡MARCKS重组蛋白
  • 货号：
    CSB-EP013493CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    鸡MARCKS重组蛋白
  • 货号：
    CSB-EP013493CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    鸡MARCKS重组蛋白
  • 货号：
    CSB-BP013493CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    鸡MARCKS重组蛋白
  • 货号：
    CSB-MP013493CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    MARCKSMyristoylated alanine-rich C-kinase substrate; MARCKS
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-281
  • 氨基酸序列
    GAQFSKTAA KGEAAAEKPG EAVAASPSKA NGQENGHVKV NGDASPAAAE AGKEEVQANG SAPAEETGKE EAASSEPASE KEAAEAESTE PASPAEGEAS PKTEEGATPS SSSETPKKKK KRFSFKKSFK LSGFSFKKNK KEAGEGAESE GGAAAAAEGG KEEAAAAAPE AAGGEEGKAA AEEASAAAAG SREAAKEEAG DSQEAKSDEA APEKATGEEA PAAEEQQQQQ QQEKAAEEAG AAATSEAGSG EQEAAPAEEP AAARQEAPSE SSPEGPAEPA E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
  • 基因功能参考文献：
    1. MARCKS phosphorylation does not cause extensive modifications in the peptide structure. PMID: 24590112
    2. In conclusion, MARCKS is present and phosphorylated at early stages during the differentiation of PNS cells and precursors, indicating that it might also be important for the differentiation of these tissues. PMID: 23470634
    3. a novel consequence of PKC stimulation upon the phosphorylated state of MARCKS in neural cells PMID: 23634231
    4. findings suggest a complex regulation of MARCKS by phosphorylation during neural development PMID: 14998167
    5. The most outstanding MARCKS modifications occur at the outer retina, where S25p disappears at the end of embryonic development and where MARCKS is missing in adults. These results suggest diverse functional specializations in the different retinal layers. PMID: 15855766
    6. The results indicate that there is a learning-specific increase in membrane-bound, non-phosphorylated MARCKS 24 h after training. This increase might contribute to stabilization of synaptic morphology. PMID: 18516597
    7. these results indicate the existence of a functional interaction between actin filaments and MARCKS in cells, and particularly of an action in maintaining a phosphorylation in a region of the N-terminal moiety of MARCKS. PMID: 19366616

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Membrane; Lipid-anchor.
  • 蛋白家族：
    MARCKS family
  • 数据库链接：

    KEGG: gga:396473

    UniGene: Gga.48522