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  4. Recombinant Bovine Xanthine dehydrogenase/oxidase (XDH), partial

Recombinant Bovine Xanthine dehydrogenase/oxidase (XDH), partial

  • 中文名称：
    牛XDH重组蛋白
  • 货号：
    CSB-YP026189BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛XDH重组蛋白
  • 货号：
    CSB-EP026189BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛XDH重组蛋白
  • 货号：
    CSB-EP026189BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛XDH重组蛋白
  • 货号：
    CSB-BP026189BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛XDH重组蛋白
  • 货号：
    CSB-MP026189BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    XDH
  • Uniprot No.：
  • 别名：
    XDH; Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase; XD; EC 1.17.1.4); Xanthine oxidase; XO; EC 1.17.3.2; Xanthine oxidoreductase; XOR)]
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
  • 基因功能参考文献：
    1. S-allyl cysteine as potent anti-gout drug: Insight into the xanthine oxidase inhibition and anti-inflammatory activity. PMID: 30059711
    2. Data suggest that XDH (xanthine dehydrogenase) can be an important redox-regulated source of superoxide generation in ischemic tissue; conversion XDH to XO (xanthine oxidase) is not required to activate radical formation and subsequent tissue injury. PMID: 25243829
    3. crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase and of the reduced bovine milk enzyme [XOR] PMID: 21077683
    4. Plasma tumor necrosis factor-alpha response to either of two lipopolysaccharide challenges was lower in progesterone-treated than in 17beta-estradiol-treated steers. Xanthine oxidase response to either challenge was greater for estradiol-treated steers. PMID: 21356584
    5. 6,8-dihydroxypurine is effectively converted to uric acid by xanthine oxidase. PMID: 20615869
    6. Hydrogen peroxide is the major oxidant product of xanthine oxidase PMID: 19941951
    7. detailed insight into the essential mechanistic role of the active-site residues PMID: 19788181
    8. Phe-549, Arg-335, Trp-336, & Arg-427 form the core of a relay system for the XDH/XO transition.They gate a solvent channel leading toward the FAD ring. PMID: 12817083
    9. Results describe the formation of peroxynitrite from the simultaneous reduction of nitrite and oxygen by xanthine oxidase. PMID: 15044013
    10. Stimulation of XDH conversion to xanthine oxidase may represent a feed-forward mechanism whereby H2O2 can stimulate further production of reactive oxygen species PMID: 15905466
    11. evidence xanthine oxidase (XO) is regulated by transmembrane secretion of xanthine &/or hypoxanthine to extracellular environment; response of XO to bacteria & bacteria-dependent nitrosative stress demonstrates it is part of mammary gland immune system PMID: 17888877
    12. Substrate Orientation and Catalysis at the Molybdenum Site in Xanthine Oxidase: CRYSTAL STRUCTURES IN COMPLEX WITH XANTHINE AND LUMAZINE. PMID: 19109252

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  • 亚细胞定位：
    Cytoplasm. Peroxisome. Secreted.
  • 蛋白家族：
    Xanthine dehydrogenase family
  • 组织特异性：
    Detected in milk (at protein level).
  • 数据库链接：

    KEGG: bta:280960

    STRING: 9913.ENSBTAP00000016620

    UniGene: Bt.5403