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  4. Recombinant Bovine Metalloproteinase inhibitor 2 (TIMP2)

Recombinant Bovine Metalloproteinase inhibitor 2 (TIMP2)

  • 中文名称：
    牛TIMP2重组蛋白
  • 货号：
    CSB-YP023561BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛TIMP2重组蛋白
  • 货号：
    CSB-EP023561BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛TIMP2重组蛋白
  • 货号：
    CSB-EP023561BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛TIMP2重组蛋白
  • 货号：
    CSB-BP023561BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛TIMP2重组蛋白
  • 货号：
    CSB-MP023561BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TIMP2
  • Uniprot No.：
  • 别名：
    TIMP2; Metalloproteinase inhibitor 2; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 2; TIMP-2
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-220
  • 氨基酸序列
    CSCS PVHPQQAFCN ADIVIRAKAV NKKEVDSGND IYGNPIKRIQ YEIKQIKMFK GPDQDIEFIY TAPAAAVCGV SLDIGGKKEY LIAGKAEGNG NMHITLCDFI VPWDTLSATQ KKSLNHRYQM GCECKITRCP MIPCYISSPD ECLWMDWVTE KNINGHQAKF FACIKRSDGS CAWYRGAAPP KQEFLDIEDP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
  • 基因功能参考文献：
    1. Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB-MT1-MMP-dependent and -independent pathway. PMID: 23266860
    2. A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis. PMID: 21626345
    3. MMP-14, MMP-2 and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle. PMID: 21247626
    4. Results describe distinct changes in expression of MMP2, MMP14, and the metallopeptidase inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation. PMID: 20887771
    5. Production of TIMP-1 was augmented by IL-1alpha, TNFalpha, and hepatocyte growth factor at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments. PMID: 12606436
    6. the different temporal expression patterns of TIMP-1 and TIMP-2 suggest that TIMP-1 may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance PMID: 14613539
    7. Identification, purification and partial characterization of timp-2 in bovine pulmonary artery smooth muscle PMID: 14674707
    8. Results describe the isolation of matrix metalloproteinase 2 (MMP-2) from the MMP-2/tissue inhibitor of metalloproteinase 2 (TIMP-2) complex, and the characterization of both isolated MMP-2 and the complex itself. PMID: 15374620
    9. oxidants inactivate TIMP-2, and the resulting activation of MMP-2 subsequently inhibits Na+ dependent Ca2+ uptake in the microsomes PMID: 15792356
    10. TIMP-2 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events. PMID: 17030988
    11. Results suggest that MMP-2, MMP-9, and TIMP-2 mRNAs are expressed in bovine placentomes during the gestational and postpartum periods and that these enzymes, in conjunction with steroidogenic enzymes, mediate fetal membrane detachment after parturition. PMID: 17154296
    12. We have solved the 2.0 A crystal structure of the complex between the catalytic domain of human MMP-13 (cdMMP-13) and bovine TIMP-2. PMID: 17196980
    13. legumain and TIMP-2 mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy PMID: 18449874

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Protease inhibitor I35 (TIMP) family
  • 数据库链接：

    KEGG: bta:282093

    STRING: 9913.ENSBTAP00000014476

    UniGene: Bt.111410