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  4. Recombinant Bovine Membrane-associated progesterone receptor component 1 (PGRMC1), partial

Recombinant Bovine Membrane-associated progesterone receptor component 1 (PGRMC1), partial

  • 中文名称：
    牛PGRMC1重组蛋白
  • 货号：
    CSB-YP613768BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛PGRMC1重组蛋白
  • 货号：
    CSB-EP613768BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛PGRMC1重组蛋白
  • 货号：
    CSB-EP613768BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛PGRMC1重组蛋白
  • 货号：
    CSB-BP613768BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛PGRMC1重组蛋白
  • 货号：
    CSB-MP613768BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PGRMC1
  • Uniprot No.：
  • 别名：
    PGRMC1; Membrane-associated progesterone receptor component 1; mPR
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins.
  • 基因功能参考文献：
    1. PGRMC1 participates in late events of both mammalian mitosis and oocyte meiosis, consistent with PGRMC1's localization at the mid-zone and mid-body of the mitotic and meiotic spindle. PMID: 27260975
    2. PGRMC1 protein expression and cellular distribution in cumulus cells PMID: 25319710
    3. data indicate variable expression of progesterone receptor membrane component 1 and 2 and serpine mRNA binding protein 1 mRNA and protein in bovine corpus luteum and suggest that progesterone may regulate corpus luteum function via its membrane receptors PMID: 25168721
    4. endometrial mRNA level elevated during pregnancy is unchanged during estrous cycle PMID: 23522067
    5. Alterations in PGRMC1 and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts. PMID: 23325810
    6. Data suggest that expression of PGRMC1 in bovine oviduct is primarily in luminal epithelium and is primarily cytoplasmic. Expression of PR (progesterone receptor), PGRMC1, and PGRMC2 are not affected by pregnancy or presence of corpus luteum. PMID: 22958265
    7. analysis of expression of progesterone receptor membrane component 1, serpine mRNA binding protein 1 and nuclear progesterone receptor isoforms A and B in the bovine myometrium during the estrous cycle and early pregnancy PMID: 22277931
    8. With the exception of the corpora lutea, PGRMC1 localization showed similar pattern during different stages of the estrous cycle. PMID: 22073374
    9. PGRMC1 is expressed in bovine oocytes and its localization changes at specific stages of oocyte maturation, which may be specifically related to the mechanism by which chromosomes segregate. PMID: 20739377
    10. PGRMC1 mRNA is expressed in bovine CL and this expression varies throughout the luteal phase. It is assumed that PGRMC1 may be involved in a non-genomic effect of P(4) on luteal cells. PMID: 19092990

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  • 亚细胞定位：
    Microsome membrane; Single-pass membrane protein. Smooth endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein; Extracellular side.
  • 蛋白家族：
    Cytochrome b5 family, MAPR subfamily
  • 数据库链接：

    KEGG: bta:317706

    STRING: 9913.ENSBTAP00000026053

    UniGene: Bt.12820