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  4. Recombinant Bothrops jararaca Zinc metalloproteinase-disintegrin jararhagin

Recombinant Bothrops jararaca Zinc metalloproteinase-disintegrin jararhagin

  • 中文名称：
    Recombinant Bothrops jararaca Zinc metalloproteinase-disintegrin jararhagin,Yeast
  • 货号：
    CSB-YP326972BUW
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Bothrops jararaca Zinc metalloproteinase-disintegrin jararhagin,Yeast
  • 货号：
    CSB-EP326972BUW
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Bothrops jararaca Zinc metalloproteinase-disintegrin jararhagin,Yeast
  • 货号：
    CSB-EP326972BUW-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Bothrops jararaca Zinc metalloproteinase-disintegrin jararhagin,Yeast
  • 货号：
    CSB-BP326972BUW
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Bothrops jararaca Zinc metalloproteinase-disintegrin jararhagin,Yeast
  • 货号：
    CSB-MP326972BUW
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    ; Zinc metalloproteinase-disintegrin-like jararhagin; EC 3.4.24.73; HF2-proteinase; JG; Jararafibrase I; JF I; Snake venom metalloproteinase; SVMP) [Cleaved into: Disintegrin-like jararhagin-C; Jaracetin)]; Fragment
  • 种属：
    Bothrops jararaca (Jararaca)
  • 蛋白长度：
    full length protein
  • 表达区域：
    151-571
  • 氨基酸序列
    EQQRYDPYKY IEFFVVVDQG TVTKNNGDLD KIKARMYELA NIVNEIFRYL YMHVALVGLE IWSNGDKITV KPDVDYTLNS FAEWRKTDLL TRKKHDNAQL LTAIDFNGPT IGYAYIGSMC HPKRSVGIVQ DYSPINLVVA VIMAHEMGHN LGIHHDTGSC SCGDYPCIMG PTISNEPSKF FSNCSYIQCW DFIMNHNPEC IINEPLGTDI ISPPVCGNEL LEVGEECDCG TPENCQNECC DAATCKLKSG SQCGHGDCCE QCKFSKSGTE CRASMSECDP AEHCTGQSSE CPADVFHKNG QPCLDNYGYC YNGNCPIMYH QCYALFGADV YEAEDSCFKD NQKGNYYGYC RKENGKKIPC APEDVKCGRL YCKDNSPGQN NPCKMFYSND DEHKGMVLPG TKCADGKVCS NGHCVDVATA Y
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Snake venom zinc metalloproteinase-disintegrin-like jararhagin: causes hemorrhage. This is the result of the degradation of sub-endothelial matrix proteins leading to the disruption of the blood vessel endothelium, with accompanying disturbances in platelet function. It is able to degrade von Willebrand factor (vWF) and it hydrolyzes the alpha-chain of fibrinogen (FGA) while leaving the beta and gamma chains unaffected. It inhibits collagen-induced platelet aggregation through the binding to alpha-2/beta-1 integrin (ITGA2/ITGB1) (collagen receptor), and it cleaves the beta-1 subunit of the same integrin, inhibiting platelet interaction and ultimately causing impairment of signal transduction. It has inability to be affected by the plasma inhibitor alpha(2)-macroglobulin. In fibroblasts, it functions as a collagen-mimetic substrate and, in endothelial cells, it causes apoptosis and indirectly inhibits cell proliferation by release of angiostatin-like compounds. It induces a strong pro-inflammatory response characterized by intense leukocyte accumulation and release of cytokines at the site of the injection. Although hemorrhage and edema are a response to the direct effect of this toxin, jararhagin-induced inflammation and necrosis are dependent on macrophages and key pro-inflammatory cytokines or their receptors. It also possesses anti-tumorgenic properties.; the monomeric form inhibits collagen- and ADP-induced platelet aggregation, but has no effect on glycoprotein Ib-IX-dependent (GP1BA/GP5/GP9) platelet agglutination. Locally activates the early events of an acute inflammatory response as leukocyte rolling and pro-inflammatory cytokine release.; the dimeric form jaracetin may be a dimeric form of jararhagin-C. It binds to von Willebrand factor (VWF) and induces its interaction with GPIbalpha (GP1BA) (via the vWF A1 domain), resulting in platelet aggregation. Also binds the alpha-2 subunit of the alpha-2/beta-1 (ITGA2/ITGB1) integrin. It potently induces platelet aggregation in citrated platelet-rich plasma.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Venom metalloproteinase (M12B) family, P-III subfamily, P-IIIb sub-subfamily
  • 组织特异性：
    Expressed by the venom gland.
  • 数据库链接：

    KEGG: ag:CAA48323