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  4. Recombinant Bordetella pertussis Pertussis toxin subunit 2 (ptxB)

Recombinant Bordetella pertussis Pertussis toxin subunit 2 (ptxB)

  • 中文名称：
    百日咳博德特氏菌ptxB重组蛋白
  • 货号：
    CSB-YP361433BUA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    百日咳博德特氏菌ptxB重组蛋白
  • 货号：
    CSB-EP361433BUA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    百日咳博德特氏菌ptxB重组蛋白
  • 货号：
    CSB-EP361433BUA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    百日咳博德特氏菌ptxB重组蛋白
  • 货号：
    CSB-BP361433BUA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    百日咳博德特氏菌ptxB重组蛋白
  • 货号：
    CSB-MP361433BUA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ptxB
  • Uniprot No.：
  • 别名：
    ptxB; BP3784; Pertussis toxin subunit 2; PTX S2; Islet-activating protein S2; IAP S2
  • 种属：
    Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-226
  • 氨基酸序列
    STP GIVIPPQEQI TQHGGPYGRC ANKTRALTVA ELRGSGDLQE YLRHVTRGWS IFALYDGTYL GGEYGGVIKD GTPGGAFDLK TTFCIMTTRN TGQPATDHYY SNVTATRLLS STNSRLCAVF VRSGQPVIGA CTSPYDGKYW SMYSRLRKML YLIYVAGISV RVHVSKEEQY YDYEDATFET YALTGISICN PGSSLC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.
  • 基因功能参考文献：
    1. Pertussis toxin B oligomer (PTX-B) inhibits both transcription and secretion of transforming growth factor (TGF)-beta elicited by HIV-1 Tat in NK cells. PMID: 15879099
    2. Data show that toxin analogs containing two S3 subunits and lacking S2, or containing two S2 subunits and lacking S3, can be produced, assembled and secreted by B. pertussis strains. PMID: 16689799
    3. Pertussis toxin subunit B causes desensitization of related chemokine receptor CXCR4; inhibition of CXCR4 by PTxB is rapid and transient; however, the catalytic activity of PTx prevents CXCR4 signaling in the long term. PMID: 19380820
  • 亚细胞定位：
    Secreted. Host cell membrane.
  • 蛋白家族：
    Pertussis toxin S2/S3 subunits family
  • 数据库链接：

    KEGG: bpe:BP3784

    STRING: 257313.BP3784