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  4. Recombinant Anemonia sulcata Antihypertensive protein BDS-2

Recombinant Anemonia sulcata Antihypertensive protein BDS-2

  • 中文名称：
    Recombinant Anemonia sulcata Antihypertensive protein BDS-2,Yeast
  • 货号：
    CSB-YP348477AKE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Anemonia sulcata Antihypertensive protein BDS-2,Yeast
  • 货号：
    CSB-EP348477AKE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Anemonia sulcata Antihypertensive protein BDS-2,Yeast
  • 货号：
    CSB-EP348477AKE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Anemonia sulcata Antihypertensive protein BDS-2,Yeast
  • 货号：
    CSB-BP348477AKE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Anemonia sulcata Antihypertensive protein BDS-2,Yeast
  • 货号：
    CSB-MP348477AKE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    DeltaKappa-actitoxin-Avd4b; DeltaKappa-AITX-Avd4b; Antihypertensive protein BDS-2; Blood depressing substance II; BDS-II
  • 种属：
    Anemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-43
  • 氨基酸序列
    AAPCFCPGKP DRGDLWILRG TCPGGYGYTS NCYKWPNICC YPH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a gating modifier on both Kv and Nav ion channels. Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4). Slows inactivation of the voltage-gated sodium channel Nav1.7/SCN9A. Inhibits all Kv3.1, Kv3.2 and Kv3.4 by about 50% when tested at a voltage of +40 mV. May act by binding residues in voltage-sensing domains S3b and S4 of Kv3. Tests have been done on human Nav1.7/SCN9A and rat SCG neurons that mostly carry Nav1.7 channels (EC(50)=300 nM). This toxin also reduces blood pressure (Ref.1).
  • 亚细胞定位：
    Secreted. Nematocyst.
  • 蛋白家族：
    Sea anemone type 3 (BDS) potassium channel toxin family