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ZAK Antibody

  • 中文名称：
    ZAK兔多克隆抗体
  • 货号：
    CSB-PA030032
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9NYL2
  • 基因名：
  • 别名：
    AZK antibody; Cervical cancer suppressor gene 4 protein antibody; HCCS 4 antibody; HCCS-4 antibody; HCCS4 antibody; Human cervical cancer suppressor gene 4 protein antibody; Leucine zipper and sterile alpha motif containing kinase antibody; Leucine zipper- and sterile alpha motif-containing kinase antibody; Mitogen activated protein kinase kinase kinase MLT antibody; Mitogen-activated protein kinase kinase kinase MLT antibody; Mixed lineage kinase 7 antibody; Mixed lineage kinase related kinase antibody; Mixed lineage kinase related kinase MRK beta antibody; Mixed lineage kinase with a leucine zipper and a sterile alpha motif antibody; Mixed lineage kinase-related kinase antibody; MLK 7 antibody; MLK like mitogen activated protein triple kinase antibody; MLK related kinase antibody; MLK-like mitogen-activated protein triple kinase antibody; MLK-related kinase antibody; MLK7 antibody; Mlklak antibody; MLT antibody; MLTK_HUMAN antibody; MRK antibody; Sterile alpha motif and leucine zipper containing kinase AZK antibody; Sterile alpha motif- and leucine zipper-containing kinase AZK antibody; Zak antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human MLTK around the non-phosphorylation site of S165.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Involved in limb development.; Phosphorylates histone H3 at 'Ser-28'. May have role in neoplastic cell transformation and cancer development. Causes cell shrinkage and disruption of actin stress fibers.
  • 基因功能参考文献：
    1. The ZAK rs3769201 and rs722864 may be functional susceptibility loci for lung cancer risk. PMID: 29071797
    2. The expression of ZAKbeta is dependent on ZAKalpha expression, and ZAKbeta further enhances ZAKalpha expression and results in synergistic enhancement of apoptosis in osteosarcoma cells. PMID: 29654619
    3. Gene set enrichment analysis disclosed a significant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK/ERK and motility-related signaling pathways of the reactome database, strongly suggesting that ZAK induces such pro-tumoral reaction cascades in human cancers. PMID: 26522728
    4. Recessive mutations in the kinase ZAK - novel cause of congenital myopathy. PMID: 27816943
    5. ZAK is a key player in mammalian limb patterning in humans and mice. PMID: 26755636
    6. ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers. PMID: 24807215
    7. The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK pathway. PMID: 25013376
    8. we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun-NH(2)-kinase (JNK) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK) PMID: 24170769
    9. MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38 PMID: 23319595
    10. The genes identified KTN1, ROCK1, and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone PMID: 21305317
    11. decrease of lung cancer cell proliferation by ZAK may involve the ERK and JNK pathways via an AP-1 transcription factor. PMID: 20331627
    12. In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1, and show that MRK-beta could also activate MSK1 through direct interaction. PMID: 20408143
    13. Results suggest that ZAK might play a role as an upstream signal to suppress the ZZaPK function and decrease E2F expression. PMID: 12535642
    14. Data show that in response to radiation, MRK controls two independent pathways: the Chk2-Cdc25A pathway leading to cell cycle arrest and the p38gamma MAPK pathway PMID: 15342622
    15. Results suggest that a ZAK mediates TGF-beta-induced cardiac hypertrophic growth via a novel TGF-beta signaling pathway. PMID: 15465036
    16. ZAK induces characteristic hypertrophic growth features, including increased cell size, elevated atrial natriuretic factor expression, and increased actin fiber organization PMID: 15485649
    17. Mixed lineage kinase 7 (MLK7), a splice variant of the ZAK gene, encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation. PMID: 15737997
    18. data demonstrate that a ZAK isoform(s) is the MAP3Kinase that transduces the ribotoxic stress response PMID: 18331592

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  • 相关疾病：
    Split-foot malformation with mesoaxial polydactyly (SFMMP)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 组织特异性：
    Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
  • 数据库链接：

    HGNC: 17797

    OMIM: 609479

    KEGG: hsa:51776

    STRING: 9606.ENSP00000364361

    UniGene: Hs.444451