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SARNP Antibody

  • 货号：
    CSB-PA070014
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P82979
  • 基因名：
    SARNP
  • 别名：
    Cytokine induced protein of 29 kDa antibody; Cytokine-induced protein of 29 kDa antibody; HCC 1 antibody; HCC1 antibody; HSPC316 antibody; Nuclear protein Hcc 1 antibody; Nuclear protein Hcc-1 antibody; Proliferation associated cytokine inducible protein CIP29 antibody; Proliferation-associated cytokine-inducible protein CIP29 antibody; SAP domain-containing ribonucleoprotein antibody; SARNP antibody; SARNP_HUMAN antibody; THO1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human CIP29.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
  • 基因功能参考文献：
    1. Herein, the s extend their previous research and provide evidence that ORF57 of human herpesvirus-8 interacts with CHTOP and CIP29, in contrast to POLDIP3. PMID: 27189710
    2. CIP29 appears to be a new cytokine regulated protein involved in normal and cancer cell proliferation. PMID: 11922608
    3. Hcc-1 plays a role in growth regulation and nucleic acids metabolism. PMID: 15338056
    4. CIP29 physically and functionally associates with DDX39, suggesting their cooperation in the RNA metabolism. PMID: 17196963
  • 亚细胞定位：
    Nucleus. Nucleus speckle.
  • 组织特异性：
    Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma.
  • 数据库链接：

    HGNC: 24432

    OMIM: 610049

    KEGG: hsa:84324

    STRING: 9606.ENSP00000337632

    UniGene: Hs.505676