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GABRA3 Antibody

  • 中文名称：
    GABRA3兔多克隆抗体
  • 货号：
    CSB-PA009142GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P34903
  • 基因名：
    GABRA3
  • 别名：
    GABA A Receptor alpha 3 antibody; GABA(A) receptor subunit alpha 3 antibody; GABA(A) receptor subunit alpha-3 antibody; GABR A3 antibody; GABRA 3 antibody; Gabra3 antibody; Gamma aminobutyric acid (GABA) A receptor alpha 3 antibody; Gamma aminobutyric acid A receptor alpha 3 antibody; Gamma aminobutyric acid receptor subunit alpha 3 antibody; Gamma-aminobutyric acid receptor subunit alpha-3 antibody; GBRA3_HUMAN antibody; MGC33793 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GABRA3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 基因功能参考文献：
    1. The GABRA3 found distribute in intercalated nucleui of amygdala and dentate gyrus. PMID: 29023704
    2. These small-molecule GlyR PAMs have high potential both as early tool compounds to enable pharmacological studies of GlyR inhibitory neurotransmission and as a starting point for the development of potent, selective GlyRalpha3 PAMs as novel analgesics. PMID: 27412533
    3. GABRA3 induced MMP-2 and MMP-9 expression through activation of the JNK/AP-1 signaling pathway, promoting lymphatic metastasis in lung adenocarcinoma. PMID: 27081042
    4. Five missense variants and one microduplication were detected in four families and two sporadic cases presenting with a range of epileptic seizure types, a varying degree of intellectual disability and developmental delay, sometimes with dysmorphic features or nystagmus. PMID: 29053855
    5. The alpha3-immunoreactivity in the cerebellar cortex was relatively weak, but it was abundantly observed in different cell populations in the subcortical cerebellar structures PMID: 26518133
    6. Gabra3 activates the AKT pathway to promote breast cancer cell migration, invasion and metastasis. The A-to-I RNA-edited form of Gabra3 is found only in non-invasive breast cancers. Edited Gabra3 suppresses breast cancer cell invasion and metastasis. PMID: 26869349
    7. The N-terminal region of GABRA3 and the GlyR beta subunit occupies the same binding site of gephyrin. PMID: 25531214
    8. high expression of GABBR2 with a low expression of GABR(A3) may predict a better outcome in non-small cell lung cancer PMID: 23617850
    9. A novel role for GA-repeat core promoter to regulate gene expression in the genes such as GABRA3 involved in development and evolution. PMID: 24055488
    10. We identified truncating mutations in distinct X-linked gamma-aminobutyric acid A (GABAA) receptor subunit-encoding genes, GABRQ and GABRA3.this is the first report of ASD patients with truncating mutations in GABA receptors genes. PMID: 23169495
    11. Endogenous potentiation of GABAergic synaptic transmission and responses to GABA uncaging in the thalamic reticular nucleus is absent in mice in which benzodiazepine binding to alpha3 subunit-containing GABAARs is disrupted. PMID: 23727119
    12. In subjects with schizophrenia, GABA A alpha3 receptor expression is 14% higher in layer 2 of the dorsolateral prefrontal cortex. PMID: 20843900
    13. The results indicate that there may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 and GABBR2 genes. PMID: 21971078
    14. The ratios of beta(3)/beta(2) and alpha(5)/alpha(1) subunit protein expression in Angelman syndrome cortex were significantly decreased when compared with controls. PMID: 20692323
    15. GABRA3 gene was overexpressed in lung cancer and rarely expressed in other cancers PMID: 19048400
    16. The results of our study indicate that GABRA 3 gene might also be involved in the genetic pathophysiology of unipolar major depressive disorder PMID: 15048654
    17. 3 of GABRA3 are found to be associated with THPP PMID: 17970773
    18. In the SNr GABA(A) receptors contain alpha(1), alpha(3), beta(2,3), and gamma(2) subunits and are localized in a weblike network over the cell soma, dendrites, and spines of SNr parvalbumin-positive nonpigmented neurons. PMID: 18085588
    19. Data show that GABRA3 is significant reductions in parietal cortex in subjects with autism. PMID: 18821008
    20. GABA and GABRA3 play important roles in hepatocellular carcinoma (HCC) development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC. PMID: 19084931

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA3 sub-subfamily
  • 数据库链接：

    HGNC: 4077

    OMIM: 305660

    KEGG: hsa:2556

    STRING: 9606.ENSP00000359334

    UniGene: Hs.123024