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CKLF Antibody

  • 中文名称：
    CKLF兔多克隆抗体
  • 货号：
    CSB-PA656806
  • 规格：
    ￥880
  • 图片：
    • Western blot analysis of 3T3 lysis using CKLF antibody.. Secondary antibody was diluted at 1:20000
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBR5
  • 基因名：
    CKLF
  • 别名：
    CKLF; CKLF1; HSPC224; UNQ410/PRO772; Chemokine-like factor; C32
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human C32.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.; has chemotactic response in monocytes, neutrophils and lymphocytes. Binds CCR4.
  • 基因功能参考文献：
    1. Data indicate that leukocyte-infiltrate derived chemokine-like factor (CKLF) expression is a candidate biomarker of favorable prognosis. PMID: 27153559
    2. CKLF1 expression was up-regulated in synovim from rheumatoid arthritis and ankylosing spondylitis patients. PMID: 26838743
    3. expression elevated in the skin of keloid patients PMID: 26986142
    4. role in the pathogenesis of psoriasis by promoting the proliferation of microvascular endothelial cells PMID: 25915746
    5. Chemokine-like factor 1 is over-expressed in patients with atopic dermatitis. PMID: 23983609
    6. CKLF1 can induce proliferation and inhibit apoptosis of human vascular smooth muscle cell through the down-regulation of Bax and Caspase-3 and the up-regulation of Bcl-2 expression. PMID: 23253812
    7. The expression of CKLF1 is up-regulated in atherosclerotic plaques. PMID: 20137403
    8. CKLF1-C19 and -C27 can stimulate antigen-presenting capability of dendritic cells PMID: 20392439
    9. CKLF1 could increase the proliferation of human bone marrow hematopoietic progenitor cells and colony formation PMID: 12411060
    10. Results confirm that the secreted peptides of CKLF1, C27 and C19, have functional activation via CCR4. PMID: 18069042
    11. Chemokine-like factor expression is differentially regulated in myoblasts and myotubes and thrombin could be a strong regulator for its expression PMID: 18294340

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  • 亚细胞定位：
    [Isoform 1]: Secreted.; [Isoform 2]: Membrane; Multi-pass membrane protein.; [Isoform 4]: Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chemokine-like factor family
  • 组织特异性：
    Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skel
  • 数据库链接：

    HGNC: 13253

    OMIM: 616074

    KEGG: hsa:51192

    STRING: 9606.ENSP00000264001

    UniGene: Hs.15159