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Recombinant Rat Shootin-1

  • 货号：
    CSB-YP012273RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP012273RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP012273RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP012273RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP012273RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Shtn1
  • Uniprot No.：
  • 别名：
    Shtn1; Shootin-1; Shootin1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-633
  • 氨基酸序列
    MNSSDEEKQL QLITSLKEQA IGEYEDLRAE NQKTKETCDK IRQERDEAVK KLEEFQKISH MVIEEVNFMQ NHLEIEKTCR ESAEALATKL NKENKTLKRI SMLYMAKLGP DVITEEINID DDDPGTDTDA AAETCVSVQC QKQIKELRDQ IVSVQEEKKV LAIELESLKS KLGEVMEEVN KVKQEKAVLN SEVLEQRKVL EKCNRVSVLA VEEYEELQVN LELEKDLRKK AESFAQEMFI EQNKLKRQSH LLLQSSLPDQ QLLKALDENA KLIQQLEEER IQHQQKVKEL EERLENEALH KEIHNLRQQL ELLEDDKREL EQKYQSSEEK ARNLKHSVDE LQKRVNQSEN SVPPPPPPPP PLPPPPPNPI RSLMSMIRKR SHPSGGSTKK EKATQPETAE EVTDLKRQAV EEMMDRIKKG VHLRPVNQTA RPKAKPDSLK GSESAVDELK GILGTLNKST SSRSLKSLGP ENSETELERI LRRRKLTAEA DSSSPTGILA TSESKSMPVL GSVSSVTKSA LNKKTLEAEF NNPCPLTPEP GEGPRKLEGC TNSKVTFQPP SKGGYRRKCV GSENQSEPVV VLDPVSTHEP QTKDQAAEKD PTQCKEEERG ETQPEFKEDS SGGKTGETDS SNC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
  • 基因功能参考文献：
    1. These results suggest that shootin1b may function in various peripheral tissues including epithelial cells. PMID: 27177867
    2. Shootin1 is involved in the generation of internal asymmetric signals required for neuronal polarization. PMID: 17030985
  • 亚细胞定位：
    Perikaryon. Cell projection, axon. Cell projection, growth cone. Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, lamellipodium.
  • 蛋白家族：
    Shootin family
  • 组织特异性：
    Brain-specific (at protein level). Expressed in hippocampal neurons.
  • 数据库链接：

    KEGG: rno:292139

    STRING: 10116.ENSRNOP00000061843

    UniGene: Rn.16095