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  4. Recombinant Rat Muscle-related coiled-coil protein (Murc)

Recombinant Rat Muscle-related coiled-coil protein (Murc)

  • 货号：
    CSB-YP015239RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015239RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015239RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015239RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015239RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cavin4
  • Uniprot No.：
  • 别名：
    Cavin4; MurcCaveolae-associated protein 4; Muscle-related coiled-coil protein; Muscle-restricted coiled-coil protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-362
  • 氨基酸序列
    MEHNGSASNA GKIHQNRLSS VTEDEDQDAA LTIVTVLDRV ATVVDSVQAS QKRIEERHRE MGNAIKSVQI DLLKLSQSHS NTGYVVNKLF EKTRKVSAHI KDVKARVEKQ QVRVTKVETK QEEIMKKNKF RVVIFQEDVP CPASLSVVKD RSLPENEEEA EEVFDPPIDL SSDEEYYVEE SRSARLRKSG KEHIDHIKKA FSKENMQKTR QNFDKKVSGI RTRIVTPERR ERLRQSGERL RQSGERLRQS GERFKKSISN ATPSKEAFKI RSLRKPKDPK AEGQEVDRGM GVDIISGSLA LGPIHEFHSD GFSETEKEVT KVGYIPQEGG DPPTPEPLKV TFKPQVRVED DESLLLELKQ SS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes. Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.
  • 基因功能参考文献：
    1. MURC modulates RhoA signaling, and MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias. PMID: 18332105
  • 亚细胞定位：
    Cytoplasm, myofibril, sarcomere. Cytoplasm. Cytoplasm, cytosol. Cell membrane, sarcolemma. Membrane, caveola. Cell membrane.
  • 蛋白家族：
    CAVIN family
  • 组织特异性：
    Expressed at much higher levels in cardiomyocytes than in non-cardiomyocytes.
  • 数据库链接：

    KEGG: rno:313225

    UniGene: Rn.218700