Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Protein E6 (E6)

Recombinant Protein E6 (E6)

  • 货号：
    CSB-YP361987HNV
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP361987HNV
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP361987HNV-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP361987HNV
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP361987HNV
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    E6; Protein E6
  • 种属：
    Human papillomavirus type 5
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-157
  • 氨基酸序列
    MAEGAEHQQK LTEKDKAELP LSIRDLAEAL GIPVIDCLIP CNFCGNFLNY LEACEFDYKR LSLIWKDYCV FACCRVCCGA TATYEFNQFY EQTVLGRDIE LASGLSIFDI DIRCQTCLAF LDIIEKLDCC GRGLPFHKVR NAWKGICRQC KHFYHDW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.
  • 基因功能参考文献：
    1. Data show that E3 ubiquitin-protein ligase HERC1 interacts with bcl-2 homologous antagonist-killer protein BAK in HPV5 E6-expressing cells that have been damaged by UV. PMID: 25408501
    2. Beta human papillomavirus E6 expression inhibits stabilization of p53 and increases tolerance of genomic instability. PMID: 24648447
    3. The C-terminal sequence of papillomavirus 5 E6 proteins alters localization and signalling of beta1-integrin to promote cell migration. PMID: 24154967
    4. s show that human papillomavirus type 5 and 8 E6 are capable of reducing the steady state levels of another p53 modifying enzyme, ATM, and as a result restrict LINE-1 retrotransposition. PMID: 23706308
    5. data demonstrate that beta-HPV E6 expression can enhance the carcinogenic potential of UVB exposure by promoting p300 degradation, resulting in a reduction in ATR levels, which leads to increased thymine dimer persistence and increased UVB induced double strand breaks PMID: 22807682
    6. Beta-HPV 5 and 8 E6 degrade p300 in a proteasomal-dependent, E6AP-independent manner. E6 competes with AKT for binding to p300. PMID: 21901101
    7. Human papillomavirus type 5 E6 oncoprotein represses the transforming growth factor beta signaling pathway by binding to SMAD3. PMID: 17020941

    显示更多

    收起更多

  • 亚细胞定位：
    Host cytoplasm. Host nucleus.
  • 蛋白家族：
    Papillomaviridae E6 protein family
  • 数据库链接：

    KEGG: vg:1489047