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  4. Recombinant Mouse Tripartite motif-containing protein 10 (Trim10)

Recombinant Mouse Tripartite motif-containing protein 10 (Trim10)

  • 中文名称：
    小鼠Trim10重组蛋白
  • 货号：
    CSB-YP895750MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Trim10重组蛋白
  • 货号：
    CSB-EP895750MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Trim10重组蛋白
  • 货号：
    CSB-EP895750MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Trim10重组蛋白
  • 货号：
    CSB-BP895750MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Trim10重组蛋白
  • 货号：
    CSB-MP895750MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trim10
  • Uniprot No.：
  • 别名：
    Trim10; Herf1; Rnf9; Tripartite motif-containing protein 10; Hematopoietic RING finger 1; RING finger protein 9
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-489
  • 氨基酸序列
    MASAPSVTSL ADEVNCPICQ GTLREPVTID CGHNFCRGCL TRYCEIPGPE SEESLSCPLC KEPFRPGSFR PNWQLANVVE NIERLQLAST RGLEVEDACP EHGEKIYFFC EEDEAQLCVV CRETGQHGAH TVRFLEDAAG PYREQIQKCL VCLRKEREEI QETQSRENKR IQVLLTQVAT KRQQVISQFA HLSQFLQQQQ TALLAQLEGL DGDILKQQEE FDSLATGEIC RFSTLIEELE EKNKRTARGL LTDIRSTLIR CETRKCRKPE AISPELGQRI RDFPQQAIPL RQEMKTFLEK LCFELDYEPA HISLDPQTSH PKLLLSEDHR RARFSYKWQN SPDTPQRFDR VTCVLAQCGF TGGRHTWMVN VDLAHGGSCT VGVVREDVRR KGELRLRPEE GIWAVRLAWG FVSALGSFPT RLALEEQPRK VQVSLDYEVG WITFVNAVTQ EHIYTFTASF TQKIFPLFGL WGRGSSFSLS CQEGAVSLL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling. In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1.
  • 基因功能参考文献：
    1. Primary Spi-1/PU.1 downregulation acts on late erythroid differentiation through at least two pathways, one of which requires TRIM10/HERF1 upregulation and parallels the Spi-1/PU.1-induced Fli-1 shutoff regulatory cascade. PMID: 18560381
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Expressed in embryonic liver.
  • 数据库链接：

    KEGG: mmu:19824

    STRING: 10090.ENSMUSP00000057928

    UniGene: Mm.299155