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  4. Recombinant Mouse Heterochromatin protein 1-binding protein 3 (Hp1bp3)

Recombinant Mouse Heterochromatin protein 1-binding protein 3 (Hp1bp3)

  • 中文名称：
    小鼠Hp1bp3重组蛋白
  • 货号：
    CSB-YP659693MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hp1bp3重组蛋白
  • 货号：
    CSB-EP659693MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hp1bp3重组蛋白
  • 货号：
    CSB-EP659693MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hp1bp3重组蛋白
  • 货号：
    CSB-BP659693MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hp1bp3重组蛋白
  • 货号：
    CSB-MP659693MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hp1bp3
  • Uniprot No.：
  • 别名：
    Hp1bp3Heterochromatin protein 1-binding protein 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-554
  • 氨基酸序列
    ATDMSQGEL IHPKALPLIV GAQLIHADKL GEKAEDTTMP IRRAVNSTRE TPPKSKLAEG EEEKPEPDGS SEESISTVEE QENETPPATS SEAEQPKGEP ESGEKEENNN KSAEEPKKDE KDQSKEKEKK VKKTIPAWAT LSASQLARAQ RQTPMASSPR PKMDAILTEA IKACFQKTGA SVVAIRKYII HKYPSLGLER RGYLLKQALK RELNRGVIRQ VKGKGASGSF VVVQKSKPPQ KSKNRKKGSA LDPEPQVKLE DVLPLAFTRL CEPKEASYSL IRKYVSQYYP KLRVDIRPQL LKNALQRAVE RGQLEQITGK GASGTFQLKK SGEKPLLGGS LMEYAILSAI AAMNEPKTCS TTALKKYVLE NHPGANSNYQ MHLLKKTLQK CEKNGWLEQI SGKGFSGTFQ LSFPYYPSPG VLFPKKESGG SDDEDEDDDD DESSEDSEDE EPPPKRSLQK KTPAKSQGKT ASMKQRGSKP ARKVPAAQRG KVRPLPKKAP PKAKTPARKA RPSPSVIKKP SGSSSRKPIA SARKEAKLPG KGKSAMKKSF KTKK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis.
  • 基因功能参考文献：
    1. Hp1bp3 and associated molecular networks are modulators of cognitive aging. PMID: 27460150
    2. Hp1bp3(-/-) females showed no deficits in behaviors often associated with impaired maternal care, including social behavior, depression, motor coordination and olfactory capability; and maintained unchanged anxiety-associated hallmarks such as cholinergic status and brain miRNA profiles. Results suggest a novel role for HP1BP3 in regulating maternal and anxiety-related behavior in mice PMID: 27470444
    3. Loss of Hp1bp3 expression is associated with cognitive decline in both mice and humans. PMID: 27460150
    4. Study identified Hp1bp3 overexpression as a potential novel marker for intrinsic 5-5-Fluorouracil resistance in colon cancer . PMID: 26976970
    5. HP1BP3 plays a key role in normal growth and bone development by regulating transcription of endocrine IGF-1 components. PMID: 26402843
    6. HP1BP3 regulates hepatic expression of IGF-1 and its binding proteins, thus regulating the endocrine IGF-1 pathway. PMID: 26402843
    7. The results suggest that HP1BP3 is a ubiquitous histone H1 like nuclear protein with distinct and non-redundant functions necessary for survival and growth. PMID: 25662603

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 数据库链接：

    KEGG: mmu:15441

    STRING: 10090.ENSMUSP00000030541

    UniGene: Mm.348429