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  4. Recombinant Mouse HORMA domain-containing protein 2 (Hormad2)

Recombinant Mouse HORMA domain-containing protein 2 (Hormad2)

  • 中文名称：
    小鼠Hormad2重组蛋白
  • 货号：
    CSB-YP719384MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hormad2重组蛋白
  • 货号：
    CSB-EP719384MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hormad2重组蛋白
  • 货号：
    CSB-EP719384MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hormad2重组蛋白
  • 货号：
    CSB-BP719384MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hormad2重组蛋白
  • 货号：
    CSB-MP719384MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hormad2
  • Uniprot No.：
  • 别名：
    Hormad2; HORMA domain-containing protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-306
  • 氨基酸序列
    MATAQLSHNT RTLKASKNTI FPSQVTNEHE SLVVVKKLFA TCISCITYLR GLFPESSYRD RRLDDLSLKI LREDKKCPGS LHIIKWIQGC FDALEKRYLH MAVLTLYTNP KEPEKVTEIY QFRFKYTKKG TTMDFDSSST SFESGTDSED IKKACSLLIR QLYILMQNLG PLPNDVILTM KLHYYNSVTP HDYQPPGFKE AVNSHFLLFE GEPVSLRMGS VSSGFHSMKV KVTTEATRML DGENSVSQDD GTTEIAHQGL DCDEEEEACG SQVQRMNFVH IEPSFESSRK KKKVSEPVTV FIPNRK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation.
  • 基因功能参考文献：
    1. A HORMAD2-dependent quality control mechanism that recognizes unsynapsis and recruits ATR activity during mammalian meiosis. PMID: 23039116
    2. these observations strongly suggest that HORMAD2-dependent recruitment of ATR to unsynapsed chromosome axes constitutes a mechanism for the surveillance of asynapsis. PMID: 22549958
  • 亚细胞定位：
    Nucleus. Chromosome. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes.
  • 组织特异性：
    Specifically expressed in meiotic germ cells.
  • 数据库链接：

    KEGG: mmu:75828

    STRING: 10090.ENSMUSP00000105574

    UniGene: Mm.159592