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  4. Recombinant Mouse E3 ubiquitin-protein ligase MARCH7 (41340)

Recombinant Mouse E3 ubiquitin-protein ligase MARCH7 (41340)

  • 货号：
    CSB-YP895760MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP895760MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP895760MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP895760MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP895760MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    March7
  • Uniprot No.：
  • 别名：
    Marchf7; Axot; March7; E3 ubiquitin-protein ligase MARCHF7; EC 2.3.2.27; Axotrophin; Membrane-associated RING finger protein 7; Membrane-associated RING-CH protein VII; MARCH-VII; RING-type E3 ubiquitin transferase MARCHF7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-693
  • 氨基酸序列
    MESKPSRIPR RISVQPSGSL STRMVSGNRG TSLNDSYHSR DSSFRLDSEY QSASASACAS PCQPAWYSES EIPQGARARA QTQQRDHDSK RPKLSCTNCA STSAGRNGGS GLNTVSDSSW RHSQVPRSSS MVLGSFGTDL MRERRDLDRR RESSISNLMD YNHRSGDFTT SSYVQERVPS SYSQGARPKE NAVSTLQLNS SSTNHQLPSD HQTVPSSRDS SRSSFRSHFS PRQSESFRNS SHPAFSYFSS RNETPTISNS ERGSSQRPYR ESSDNEGRRT TRRLLSRIAS SMSSTFFSRR SSQDSLNTRS LSSENYISPR TLTSQSRNNG TSSSSDVSEG RAAEASQGFR FLRRRWGLSS LSQNHSSEPE AENFNQESEG RNSGPWLSSS LRNRCTPLFS RRRREGRDES SRMSTSDVPP RSHIFRRDSN EVVHLEAQGD SLGAAANRPQ ASGASSSAAA GGSTPELPQG GRNPGLTGIL PGSLFRFAVP PALGSNLADN VMITVDIIPS GWNSTDGKND KAKSAPSRDP EKLQKIKESL LLEDSDDEEE GDLCRICQMA AASSSNLLIE PCKCTGSLQY VHQECMKKWL QAKINSGSSL EAVTTCELCK EKLQLNLEDF DIHELHRAHA NEQAEYEFIS SGLYLVVLLH LCEQSFSDMM GNTIEPSTRV RFINLARTLQ AHMEDLETSE DEF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion. May play a role in lysosome homeostasis.
  • 基因功能参考文献：
    1. Data demonstrate that T cells retain responsiveness to a LIF/Nanog axis and that this axis is linked to MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor. PMID: 20962578
    2. Data suggest that thymic Foxp3+T cell development is influenced by axotrophin. PMID: 17161353
  • 组织特异性：
    Expressed in brain, thymus, muscle and kidney.
  • 数据库链接：

    KEGG: mmu:57438

    STRING: 10090.ENSMUSP00000068961

    UniGene: Mm.260635