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  4. Recombinant Mouse DNA repair protein complementing XP-A cells homolog (Xpa)

Recombinant Mouse DNA repair protein complementing XP-A cells homolog (Xpa)

  • 货号：
    CSB-YP731040MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP731040MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP731040MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP731040MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP731040MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Xpa; Xpac; DNA repair protein complementing XP-A cells homolog; Xeroderma pigmentosum group A-complementing protein homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-272
  • 氨基酸序列
    ATAEEKQTS PEPVAADEPA QLPAAVRASV ERKRQRALML RQARLAARPY PAAAATGGVA SVKAAPKMID TKGGFILEEE EEKHEIGNIV HEPGPVMEFD YTICEECGKE FMDSYLMNHF DLPTCDSCRD ADDKHKLITK TEAKQEYLLK DCDLEKREPA LRFLVKKNPR HSQWGDMKLY LKLQVVKRAL EVWGSQEALE DAKEVRQENR EKMKQKKFDK KVKELRRAIR SSVWKRETTT HQHKYGPEEN LEDDMYRKTC TLCGHELTYE KM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
  • 基因功能参考文献：
    1. The s' results suggest that lack of the DNA repair factor XPA may delay neurobehavioral recovery after TBI PMID: 22462511
    2. Oxidized glycerophosphocholines play a pivotal role in the photosensitivity associated with the deficiency of XPA. PMID: 22303003
    3. The tissue-specific effect of Xpa deficiency represents a novel finding; it suggests that tissue-to-tissue variation in CAG repeat instability arises, in part, by different underlying mechanisms. PMID: 21926083
    4. The circadian oscillation of XPA is achieved both by regulation of transcription by the core circadian clock proteins including cryptochrome and by regulation at the posttranslational level by the HERC2 ubiquitin ligase. PMID: 20304803
    5. The Xpa/p53+/- mouse model is an excellent candidate for a future replacement of the chronic mouse bioassay for certain classes of chemicals. PMID: 11695546
    6. Xeroderma pigmentosum group A (XPA) gene-deficient mice cannot repair UV-induced DNA damage and easily develop skin cancers by UV irradiation. UVB-induced local and systemic immunosuppression was greatly enhanced in the (-/-) mice. PMID: 11764287
    7. Enhanced spontaneous and aflatoxin-induced liver tumorigenesis in xeroderma pigmentosum group A gene-deficient mice PMID: 11960916
    8. XPA (-/-), SCF-Tg mice did not develop skin cancers after repeated exposures to UVB for 30 wk at a total dose of 72 J per cm(2) PMID: 15191564
    9. deficiency results in severe growth retardation and short life span PMID: 15661658
    10. Xpa-/- keratinocytes (complete nucleotide excision repair deficiency) show a rapid depletion of DNA replicating S-phase cells, a transient increase in quiescent S-phase cells (not replicating DNA), followed by massive apoptosis. PMID: 16182614
    11. The human carcinogen phenacetin acts as a weak genotoxic agent in an in vivo mouse model system in an Xpa deficient model. PMID: 16464479
    12. XPC, but not XPA, plays a significant role in the removal of oxidative DNA damage and preventing development of lung tumors PMID: 18316597
    13. Impaired spermatogenesis and elevated spontaneous tumorigenesis is associated with xeroderma pigmentosum group A gene deficient mice PMID: 18790090

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    XPA family
  • 数据库链接：

    KEGG: mmu:22590

    STRING: 10090.ENSMUSP00000030013

    UniGene: Mm.247036