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  4. Recombinant Human herpesvirus 2 Virion host shutoff protein (UL41)

Recombinant Human herpesvirus 2 Virion host shutoff protein (UL41)

  • 中文名称：
    Recombinant Human herpesvirus 2 Virion host shutoff protein(UL41),Yeast
  • 货号：
    CSB-YP300098HJW
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human herpesvirus 2 Virion host shutoff protein(UL41),Yeast
  • 货号：
    CSB-EP300098HJW
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human herpesvirus 2 Virion host shutoff protein(UL41),Yeast
  • 货号：
    CSB-EP300098HJW-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human herpesvirus 2 Virion host shutoff protein(UL41),Yeast
  • 货号：
    CSB-BP300098HJW
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human herpesvirus 2 Virion host shutoff protein(UL41),Yeast
  • 货号：
    CSB-MP300098HJW
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UL41
  • Uniprot No.：
  • 别名：
    UL41Virion host shutoff protein; Vhs; EC 3.1.27.-
  • 种属：
    Human herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-492
  • 氨基酸序列
    MGLFGMMKFA QTHHLVKRRG LRAPEGYFTP IAVDLWNVMY TLVVKYQRRY PSYDREAITL HCLCSMLRVF TQKSLFPIFV TDRGVECTEP VVFGAKAILA RTTAQCRTDE EASDVDASPP PSPITDSRPS FAFSNMRRRG HAFAPGDRGT RAAGPGPAAP SGAPSKPALR LAHLFCIRVL RALGYAYINS GQLEADDACA NLYHTNTVAY VHTTDTDLLL MGCDIVLDIS TGYIPTIHCR DLLQYFKMSY PQFLALFVRC HTDLHPNNTY ASVEDVLREC HWTAPSRSQA RRAARRERAN SRSLESMPTL TAAPVGLETR ISWTEILAQQ IAGEDDYEED PPLQPPDVAG GPRDGARSSS SEILTPPELV QVPNAQRVAE HRGYVAGRRR HVIHDAPEAL DWLPDPMTIA ELVEHRYVKY VISLISPKER GPWTLLKRLP IYQDLRDEDL ARSIVTRHIT APDIADRFLA QLWAHAPPPA FYKDVLAKFW DE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Minor structural protein that acts as an endoribonuclease during lytic infection. Degrades host mRNAs in the cytoplasm by cutting them at preferred sites, including some in regions of translation initiation. Together with inhibition of host splicing by ICP27, contributes to an overall decrease in host protein synthesis. Also, after the onset of viral transcription, accelerates the turnover of viral mRNA, thereby facilitating the sequential expression of different classes of viral genes. Binds translation initiation factors eIF4H, eIF4AI, and eIF4AII, thereby may interact directly with the translation initiation complex and thus digest specifically mRNAs. Also impedes antigen presentation by major histocompatibility complex class I and class II molecules, inhibits secretion of cytokines that would otherwise recruit lymphocytes and neutrophils cells to the site of infection and blocks the activation of dendritic cells. Impedes the alpha/beta interferon-mediated response to infection.
  • 基因功能参考文献：
    1. Together these data indicate that endoribonuclease activity must be maintained in order for vhs to disrupt stress granule formation. PMID: 27334584
    2. The identification of a specific viral protein involved in disrupting stress granule formation is a key step toward understanding how HSV-2 interacts with these antiviral structures. PMID: 25142597
    3. These findings provide the first evidence that HSV-2 vhs plays roles in selectively inhibiting TLR3 and RIG-I/Mda-5, as well as TLR2-mediated antiviral pathways and suppresses IFN-beta antiviral responses in human vaginal epithelial cells. PMID: 21632561
    4. The results indicate that vhs enzymatic activity plays a complex role in vhs-mediated type I IFN resistance during HSV-2 infection. PMID: 18234805
  • 亚细胞定位：
    Virion.
  • 蛋白家族：
    Herpesviridae VHS protein family
  • 数据库链接：

    KEGG: vg:1487328