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  4. Recombinant Human NKG2D ligand 4 (RAET1E), partial

Recombinant Human NKG2D ligand 4 (RAET1E), partial

  • 中文名称：
    人RAET1E重组蛋白
  • 货号：
    CSB-YP855052HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RAET1E重组蛋白
  • 货号：
    CSB-EP855052HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RAET1E重组蛋白
  • 货号：
    CSB-EP855052HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RAET1E重组蛋白
  • 货号：
    CSB-BP855052HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RAET1E重组蛋白
  • 货号：
    CSB-MP855052HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    bA350J20.7; LETAL; Lymphocyte effector toxicity activation ligand; MGC125308; MGC125309; N2DL-4; N2DL4; N2DL4_HUMAN; NKG2D ligand 4; NKG2D ligand 4 precursor; NKG2DL4; RAE-1-like transcript 4; RAET1E; RAET1E2; Retinoic acid early transcript 1E; RL-4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
  • 基因功能参考文献：
    1. decreased expression levels of ULBP4 in NPC tissues as compared to that in normal NP epithelial tissues. In addition, low ULBP4 expression correlated with poor OS, DFS, DMFS, and may prove to be a novel prognostic factor. PMID: 28159927
    2. Blocking the interaction of NKG2D with its ligands deleted the sensitizing effects of HCQ. In addition, we showed that HCQ did not affect the synthesis or degradation of ULBP4, but induced the translocation of ULBP4 from the cytoplasm to the cell membrane PMID: 28339029
    3. 5 of the 7 promoter polymorphisms of the RAET1E gene may disrupt transcription factor binding PMID: 26519211
    4. RAET1E promoter polymorphism has increased to nine types, and there are now 12 alleles determined by the coding exons, including one null. PMID: 26814419
    5. Patients whose tumors had high expression of RAET1E, ULBP1 and ULBP3 surviving a median of 11, 14 and 11 months, respectively, compared with disease-specific survival of 29, 30 and 25 months in patients whose tumors showed no expression of these ligands PMID: 20054857
    6. Binds the activating receptor NKG2D. PMID: 15240696
    7. immune escape mechanism of tumors via alternative splicing of ULBP RNA to generate a free soluble ULBP protein, RAET1E2, that may impair NKG2D-mediated NK cell cytotoxicity to tumors PMID: 17470428
    8. All ULBP4 splice variants (ULBP4-I, ULBP4-II and ULBP4-III) were type 1 membrane-spanning molecules and had the ability to bind with human NKG2D receptor in vitro PMID: 18544572
    9. data suggest that ULBP4 functions as a ligand for both TCRgammadelta and NKG2D and may play a key role in immune surveillance of tumor development and clearance of viral infection PMID: 19436053

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.; [Isoform 4]: Secreted.
  • 蛋白家族：
    MHC class I family
  • 组织特异性：
    Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid.
  • 数据库链接：

    HGNC: 16793

    OMIM: 609243

    KEGG: hsa:135250

    STRING: 9606.ENSP00000349709

    UniGene: Hs.511818