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  4. Recombinant Human Calcipressin-3 (RCAN3)

Recombinant Human Calcipressin-3 (RCAN3)

  • 中文名称：
    人RCAN3重组蛋白
  • 货号：
    CSB-YP891720HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RCAN3重组蛋白
  • 货号：
    CSB-EP891720HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RCAN3重组蛋白
  • 货号：
    CSB-EP891720HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RCAN3重组蛋白
  • 货号：
    CSB-BP891720HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RCAN3重组蛋白
  • 货号：
    CSB-MP891720HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RCAN3
  • Uniprot No.：
  • 别名：
    RCAN3; DSCR1L2; Calcipressin-3; Down syndrome candidate region 1-like protein 2; Myocyte-enriched calcineurin-interacting protein 3; MCIP3; Regulator of calcineurin 3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-241
  • 氨基酸序列
    MLRDTMKSWN DSQSDLCSTD QEEEEEMIFG ENEDDLDEMM DLSDLPTSLF ACSVHEAVFE AREQKERFEA LFTIYDDQVT FQLFKSFRRV RINFSKPEAA ARARIELHET DFNGQKLKLY FAQVQMSGEV RDKSYLLPPQ PVKQFLISPP ASPPVGWKQS EDAMPVINYD LLCAVSKLGP GEKYELHAGT ESTPSVVVHV CESETEEEEE TKNPKQKIAQ TRRPDPPTAA LNEPQTFDCA L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
  • 基因功能参考文献：
    1. The tumor suppressor effect of RCAN3 in breast cancer depends on the interaction with calcineurin. PMID: 25916653
    2. Studies indicate that RCAN3 is composed of a multigene system that includes at least 21 alternative spliced isoforms. PMID: 21961037
    3. Data shows RCAN3 inhibits HUVEC proliferation both basally and under VEGF or phorbol 12-myristate 13-acetate-stimulated conditions, however it does not modulate gene expression of the chosen inflammatory genes. PMID: 21042787
    4. The yeast cotransformation and GST fusion protein assay demonstrated the interaction between this new DSCR1L2 variant and the human cardiac troponin I. PMID: 16516408
    5. human RCAN3, encoded by the RCAN3 (also known as DSCR1L2) gene, interacts physically and functionally with calcineurin PMID: 17270291
    6. The interaction between TNNI3 and the new R variants of RCAN3, RCAN3-2,3,5 and RCAN3-2,4,5, is reported. PMID: 18022329

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  • 蛋白家族：
    RCAN family
  • 组织特异性：
    Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Lower expression in all other tissues.
  • 数据库链接：

    HGNC: 3042

    OMIM: 605860

    KEGG: hsa:11123

    STRING: 9606.ENSP00000363516

    UniGene: Hs.656799