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ascl1a Antibody

  • 中文名称：
    ascl1a兔多克隆抗体
  • 货号：
    CSB-PA852654LA01DIL
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) ascl1a Polyclonal antibody
  • Uniprot No.：
    Q90259
  • 基因名：
    ascl1a
  • 别名：
    ascl1a antibody; ash antibody; ash1a antibody; asha antibody; piaAchaete-scute homolog 1a antibody; Zash-1a antibody; Pituitary-absent protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Zebrafish
  • 免疫原：
    Recombinant Zebrafish Achaete-scute homolog 1a protein (1-196AA)
  • 免疫原种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ascl1a Antibody (CSB-PA852654LA01DIL)，的标记方式是Non-conjugated。对于ascl1a Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA852654LB01DIL ascl1a Antibody, HRP conjugated ELISA
    FITC CSB-PA852654LC01DIL ascl1a Antibody, FITC conjugated
    Biotin CSB-PA852654LD01DIL ascl1a Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter. Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells.
  • 基因功能参考文献：
    1. dlx1a/2a act downstream of ascl1a but upstream of dlx5a/dlx6a and gad1b to activate GABAergic specification PMID: 23747543
    2. bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine PMID: 23352790
    3. Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility PMID: 23353550
    4. Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt signaling inhibitor, Dkk, and induced expression of the Wnt ligand, Wnt4a. PMID: 21911394
    5. The Ascl1a regulates Muller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. PMID: 20935637
    6. Expressed in the postsembryonic zebrafish brain PMID: 12638130
    7. ash1a and ngn1 function in parallel redundant pathways to regulate neurogenesis downstream of flh PMID: 12702659
    8. Ascl1a might act downstream of diencephalic fibroblast growth factor 3 (Fgf3) signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis PMID: 16481349
    9. Cellular correlates of proneural gene(ash1a) expression in the regenerating zebrafish retina. PMID: 17822581
    10. ascl1a is essential for retina regeneration: within 4 h after retinal injury, ascl1a is induced in Muller glia. PMID: 18234889

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    In the 24 hours embryo, expressed in the dorsal hindbrain in two bilaterally symmetrical lines of cells marking the boundary between the alar and basal plates, and ventrally in rhombomere 1 near the floor plate. Also expressed in embryonic adenohypophysis
  • 数据库链接：

    KEGG: dre:30466

    STRING: 7955.ENSDARP00000056004

    UniGene: Dr.314