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SLC38A4 Antibody

  • 货号：
    CSB-PA021619GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q969I6
  • 基因名：
    SLC38A4
  • 别名：
    SLC38A4 antibody; ATA3 antibody; NAT3 antibody; SNAT4 antibody; Sodium-coupled neutral amino acid transporter 4 antibody; Amino acid transporter A3 antibody; Na(+)-coupled neutral amino acid transporter 4 antibody; Solute carrier family 38 member 4 antibody; System A amino acid transporter 3 antibody; System N amino acid transporter 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SLC38A4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.
  • 基因功能参考文献：
    1. three SNPs (corepressor interacting with RBPJ 1 (CIR1) rs13009079T>C, ribonucleotide reductase M1 (RRM1) rs1465952T>C and solute carrier family 38, member 4 (SLC38A4) rs2429467C>T), may play a role in the pathogenesis of lung cancer PMID: 27587543
    2. PAAT is a novel ATPase and a trans-regulator of mitochondrial ABC transporters that plays an important role in the maintenance of mitochondrial homeostasis PMID: 25063848
    3. Our results suggest that mutant allele A for SNP 1304 G>A of SLC38A4 gene is associated with hyperglycaemia. PMID: 22945694
    4. Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein PMID: 21917917
    5. evidence of SNAT4 mRNA and protein expression in the human placenta, both at the first trimester and at full term PMID: 16148032
    6. Report SNAT4 activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
    7. the contribution of SNAT4 to system A-mediated placental microvillous transport decreases between first trimester and term PMID: 19015196

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid/polyamine transporter 2 family
  • 组织特异性：
    Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels.
  • 数据库链接：

    HGNC: 14679

    OMIM: 608065

    KEGG: hsa:55089

    STRING: 9606.ENSP00000266579

    UniGene: Hs.446077