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PRDM1 Antibody

  • 货号：
    CSB-PA193485
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from JK and Raji cells using Blimp-1 Antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PRDM1 Polyclonal antibody
  • Uniprot No.：
    O75626
  • 基因名：
    PRDM1
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around aa.124~128(D-T-V-P-K) derived from Human Blimp-1
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.
  • 基因功能参考文献：
    1. The s herein prove, for the first time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas/ErbB2-mediated invasiveness. Indeed, high Blimp1 expression levels are detected in invasive p130Cas/ErbB2 cells and correlate with metastatic status in human breast cancer patients. PMID: 28442738
    2. Studied role of PR/SET domain 1 (PRDM1) protein in colon cancer; found that PRDM1beta acts as a tumor-suppressor gene in colon tumor organoids, probably by acting downstream of p53. The study also shows It modifies the expression of stem cell related genes, inhibits colon epithelial cell proliferation, and is associated with good survival in colon cancer patients. PMID: 29760071
    3. Data found that intratumoral hypoxia, which is an inevitable feature of advanced human pancreatic ductal adenocarcinoma, induces the expression of the pro-metastatic transcription factor Blimp1. The co-option of this master regulatory transcription factor is required for metastatic ability, and the molecular output of Blimp1 expression is the modulation of discrete hypoxia-induced gene expression programs. PMID: 28790031
    4. Blimp1, Foxp1 and pStat3 are expressed in extranodal diffuse large B-cell lymphomas PMID: 27924626
    5. In conclusion, aberrant coexpression of MYC and PRDM1/Blimp1alpha owing to genetic changes is responsible for the phenotype of plasmablastic lymphoma cases. PMID: 27687004
    6. Blimp-1 binds to the promoters of PD-1 and TIGIT and positively regulates their expression in patients with acute myeloid leukemia. PMID: 28629373
    7. the promoter hypermethylation of PRDM1 harbored a predominant role in the downregulation of PRDM1 expression, significantly affecting the biological behavior of tumor cells in EN-NK/T-NT. PMID: 27704586
    8. Blimp-1 suppresses the transcription of CUL4A, resulting in the maintenance of the expression of Aiolos and Ikaros. PMID: 26823144
    9. HSP70-Hrd1 axis represents a potential therapeutic target for restoring the oncorepressor activity of unstable lymphoma-associated Blimp-1 mutants. PMID: 28842558
    10. SOX2 repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase UTX to the SOX2 promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 has been shown to initiate human PGC specification, with its target PRDM1 suppressing mesendodermal genes PMID: 27132888
    11. The interaction between c-Maf and RORgammat, and Blimp-1. PMID: 28300844
    12. these results provide novel clinical and biological insight into the tumor-suppressive role of PRDM1/BLIMP-1 in ABC-DLBCL patients and suggest that loss of PRDM1/BLIMP-1 function contributes to the overall poor prognosis of ABC-DLBCL patients. PMID: 27568520
    13. PRDM1 was identified as a susceptibility gene for systemic sclerosis. PMID: 28314753
    14. Data indicate that BTG2, MAP3K11, RPS6KA1 and PRDM1 as putative targets of microRNA miR-125b. PMID: 27613090
    15. we identified MIR155HG and TERC to be transcriptionally downregulated by PRDM1 in two PRDM1-null NK-cell lines when it is ectopically expressed. These findings suggest that ZFAS1 and other dysregulated long non-coding RNAs may be involved in natural killer/T-cell lymphoma pathobiology through regulation of cancer-related genes, and loss-of-PRDM1 expression in natural killer/T-cell lymphomas tumorigenesis PMID: 28468592
    16. identified the Prdm1 gene encoding the B lymphocyte-induced maturation protein 1 as a crucial negative regulator of human TH17 cell differentiation PMID: 26976045
    17. B cell receptor signaling component, SYK, caused PAX5 tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 promoter by PAX5 was attenuated by this phosphorylation. PMID: 27181361
    18. Depletion of PRDM1 in lung cancer cells promotes cellular invasion and anoikis resistance in vitro and lung metastasis in vivo. PMID: 28378641
    19. The PRDM1 expression appeared to play an essential role in Warthin tumour pathogenesis. PMID: 25280345
    20. Blimp-1 regulates the transcription of CS1 gene in NK and B cell lines from multiple myeloma and diffuse large B cell lymphoma patients. PMID: 26310579
    21. Antineoplastic effects of liposomal short interfering RNA treatment targeting BLIMP1/PRDM1 in primary effusion lymphoma. PMID: 26206802
    22. The interaction between EBV-miR-BHRF1-2 and PRDM1 may be one of the mechanisms by which EBV-miRBHRF1-2 promotes Epstein-Barr virus lymphomagenesis. PMID: 26530011
    23. heterozygous deletion of 6q21 and/or PRDM1 was frequently detected in extranodal NK/T cell lymphoma, nasal type and correlated with downregulation of PRDM1. PMID: 26221594
    24. KLF4, together with BLIMP1, plays a critical role in mediating lytic Epstein-Barr virus reactivation in epithelial cells. PMID: 26431332
    25. aberrant methylation silencing of PRDM1alpha and hypomethylation activation of PRDM1beta are frequent events in DLBCL. PMID: 25487076
    26. Our findings suggest a previously unrecognized role of PRDM1 and human parvovirus B19 in the pathogenesis of Hashimoto thyroiditis PMID: 26475096
    27. Blimp1-deficient effector T cells fail to produce IL-10, and deficiency in Tr-1 cell function leads to uncontrolled Th17 cell-driven CNS pathology without the need to stabilize the Th17 phenotype with IL-23 PMID: 24796719
    28. Positional mapping of PRKD1, NRP1 and PRDM1 as novel candidate disease genes in truncus arteriosus PMID: 25713110
    29. Blimp-1 expression in dendritic cells can alter an innate inflammatory response by modulating the activation of myeloid cells PMID: 25826676
    30. Data show that vascular endothelial growth factor (VEGF) upregulates the transcription repressor PRD1-BF1 protein in endothelial cells. PMID: 26212250
    31. study gives no definite evidence for a pathogenic genetic link of periodontitis and RA but suggests IRF5 and PRDM1 as shared susceptibility factors. PMID: 25263394
    32. level of Blimp-1 mRNA in the monocytes from patients with active tuberculosis and latent tuberculosis infection subjects was down-regulated PMID: 26146066
    33. results expand the spectrum of lymphoid malignancies in which PRDM1 may have a tumor suppressor role and identify an epigenetic event that likely contributes to the pathogenesis of BL. PMID: 25382611
    34. peritoneal fluid mRNA level significantly elevated in endometriosis PMID: 26054109
    35. the transcriptional repressor, Blimp-1, is an intrinsic factor that predisposes CD4(+) memory T cells to latent HIV-1 infection. PMID: 25710909
    36. our results demonstrate that PRDM1 serves as a molecular switch to modulate the divergence of neural or germline fates through repression of SOX2 during human development. PMID: 24527393
    37. These data suggest that Blimp-1 might be involved in controlling the HIV reservoirs in the key central-memory T-cell subset. PMID: 24804861
    38. s conclude that BLIMP1 expression is both necessary and sufficient to induce Epstein-Barr virus lytic replication in many (possibly all) latently infected epithelial-cell types, but in only a subset of B-cell types. PMID: 25410866
    39. Single nucleotide polymorphism in PRDM1 gene is associated with Hodgkin disease therapy induced second malignancy. PMID: 24306881
    40. miR-23a and miR-125b, proved to be negatively associated with up-modulation of Blimp-1 occurring during IFN-alpha-driven dendritic cell differentiation. PMID: 23977359
    41. The failure of chronic lymphocytic leukemia cells to express or induce PRDM1 correlates with anergy. PMID: 24637363
    42. Downregulation of the tumour suppressor PRDM1 in extranodal NK/T-cell lymphoma, nasal type, is mediated by miR-223. PMID: 24438193
    43. Data indicate that B lymphocyte induced maturation protein 1 (Blimp1) mRNA expression level was 2.1 times greater in the SLE group as compared to the control group. PMID: 23911415
    44. In vitro and in vivo experiments showed that that PRDM1 is a tumor suppressor gene in anaplastic large T-cell lymphoma models, likely acting as an antiapoptotic agent. PMID: 24004669
    45. Two missense SNPs, chr6:106659789 (Ser354Asn) and chr6:106660076 (Leu450Phe) at PRDM1 on chromosome 6q21, were significantly associated with Crohn's disease and ulcerative colitis. PMID: 23624108
    46. Blimp-1 levels are translationally regulated by microRNA-9 (miR-9). PMID: 23129528
    47. found that PRDM1 was a direct target of miR-30a-5p, and PRDM1 dysfunction was attributable to miR-30a-5p-mediated repression PMID: 23348703
    48. A parent-of-origin effect in inflammatory bowel diseases was observed for single nucleotide polymorphisms in IL12B, PRDM1, and IL10. PMID: 23028907
    49. data provide evidence that abundance of Blimp-1, and consequently the secretion of proinflammatory cytokines such as IL-2, is regulated in 2 ways: (i)transcriptional regulation by activation of CD4( )T cells and (ii) posttranscriptional regulation by enhanced miR-9 expression PMID: 22585398
    50. loss of BLIMP1alpha as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas PMID: 22580854

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 数据库链接：

    HGNC: 9346

    OMIM: 603423

    KEGG: hsa:639

    STRING: 9606.ENSP00000358092

    UniGene: Hs.436023