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MYO9B Antibody

  • 货号：
    CSB-PA020012
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q13459
  • 基因名：
    MYO9B
  • 别名：
    MYO9B antibody; MYR5 antibody; Unconventional myosin-IXb antibody; Unconventional myosin-9b antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Myosin IXb.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA.
  • 基因功能参考文献：
    1. Analysis of PTPN22, ZFAT and MYO9B polymorphisms in Turner Syndrome and risk of autoimmune disease. PMID: 28627089
    2. data indicate that polymorphisms in MY09B are associated with the risk of inflammatory bowel disease PMID: 27556856
    3. Mutating either of the two arginine fingers impaired the catalytic activity of Myo9b-RhoGAP. PMID: 27363609
    4. meta-analysis indicates that MYO9B gene polymorphisms might be not associated with coeliac disease susceptibility in Caucasians. [meta-analysis] PMID: 27219348
    5. this meta-analysis shows that MYO9B genetic polymorphism is associated with Crohn's disease and ulcerative colitis PMID: 27435931
    6. newly defined SLIT/ROBO/Myo9b/RhoA signaling pathway that restricts lung cancer progression and metastasis. PMID: 26529257
    7. Our data suggest a link between MYO9B variants to an increased intestinal permeability in Crohn's disease patients. PMID: 25098938
    8. Results does not support the association of MYO9B with schizophrenia in Chinese population. PMID: 25710847
    9. MYO9B SNPs may influence the sub-phenotypic expression of Crohn's disease but did not find an association between these MYO9B polymorphisms and intestinal permeability in IBD. PMID: 24966617
    10. Variants in MYO9B may be involved in acute pancreatitis PMID: 24386489
    11. genetic variation MYO9B gene is associated with celiac disease as a protective or a risk factor PMID: 23368647
    12. The homozygous G/G group of theMyo9B polymorphism was associated with an increased risk for Barrett's esophagus and esophageal adenocarcinoms (EAC) development. Also the heterozygous A/G genotype was associated with an increased risk for EAC development. PMID: 22954106
    13. critical roles for Myo9b during epithelial wound healing and maintenance of tight junction integrity-key functions that may be altered in patients with Myo9b-linked inflammatory bowel disease. PMID: 22573889
    14. we performed genetic analysis of the MYO9B gene and the IL-2/IL-21 locus by genotyping SNPs that have been previously associated with coeliac disease or schizophrenia found no evidence for association with these two loci. PMID: 21688385
    15. These data demonstrate an association of MYO9B with ileal CD. PMID: 21515326
    16. gene polymorphism is associated with type i diabetes in Dutch but not in Brotosh population PMID: 20303373
    17. Myosin-IXb is a single-headed and processive motor PMID: 11801597
    18. myosin IXb binds to BIG1, which regulates its Rho-GTPase activating protein activity PMID: 15644318
    19. Individuals homozygous with respect to the at-risk allele have a 2.3-times higher risk of celiac disease (P = 1.55 x 10(-5)). PMID: 16282976
    20. myosin IX uses a unique ATP hydrolysis mechanism PMID: 16338935
    21. Genotyping of the three SNPs which tagged the associated haplotype was performed in a Celiac disease family dataset in a Swedish/Norwegian cohort. PMID: 16720215
    22. tested the association between celiac disease and the three most associated single nucleotide polymorphisms by the transmission disequilibrium test in the Italian population PMID: 16943798
    23. Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. PMID: 17087940
    24. Results support a negligible influence of MYO9B polymorphisms on celiac disease predisposition. PMID: 17176439
    25. The MYO9B gene rs 2305764 polymorphism is not associated to coeliac disease in coeliac children from southern Italy. The allelic frequences of the polymorphism found in these patients and in the population control were not statistically different. PMID: 17267307
    26. study suggests that genetic variation in MYO9B is associated with celiac disease, systemic lupus erythematosus, and rheumatoid arthritis and that MYO9B is a general risk factor for autoimmunity PMID: 17584584
    27. Our data and the results of our meta-analysis question the role of MYO9B as a causative gene for celiac disease. PMID: 17667713
    28. study did not confirm the association of celiac disease with the CELIAC4 region polymorphisms described in other populations PMID: 17767555
    29. demonstrate significant association of allelic variants in MYO9B with schizophrenia. To our knowledge, this is the first molecular genetic evidence for a correlation between autoimmune diseases and the risk of developing schizophrenia PMID: 17948900
    30. MYO9B homozygosity might be involved in the prognosis of CD and the chance of developing RCD II and EATL. PMID: 17967566
    31. Myosin IXB variants were not associated with coeliac disease in this study; however, weak evidence of association with dermatitis herpetiformis was found. PMID: 18077767
    32. Minor alleles of rs962917, rs2279003, and rs2305764 polymorphisms were more frequent in diabetic patients than in controls and the haplotype carrying major alleles in rs962917*G/rs2279003*C/rs2305764*G, significantly reduced the risk of type 1 diabetes PMID: 18361936
    33. No association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations PMID: 19142207
    34. MYO9B variants may be involved in inflammatory bowel disease pathogenesis PMID: 19235913

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  • 相关疾病：
    Celiac disease 4 (CELIAC4)
  • 亚细胞定位：
    Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 组织特异性：
    Detected in peripheral blood leukocytes (at protein level). Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen, testis, prostate, ovary, brain, small intestine and lung.
  • 数据库链接：

    HGNC: 7609

    OMIM: 602129

    KEGG: hsa:4650

    STRING: 9606.ENSP00000380444

    UniGene: Hs.123198