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HSD17B6 Antibody

  • 中文名称：
    HSD17B6兔多克隆抗体
  • 货号：
    CSB-PA304268
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA304268(HSD17B6 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: CSB-PA304268(HSD17B6 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    O14756
  • 基因名：
    HSD17B6
  • 别名：
    17-beta-HSD 6 antibody; 17-beta-HSD6 antibody; 17-beta-hydroxysteroid dehydrogenase type 6 antibody; 3 hydroxysteroid epimerase antibody; 3(alpha >beta) hydroxysteroid epimerase antibody; 3(alpha >beta) hydroxysteroid epimerasel antibody; 3-alpha->,beta-HSE antibody; 3-alpha->,beta-hydroxysteroid epimerase antibody; H17B6_HUMAN antibody; HSD17B6 antibody; HSE antibody; Hydroxysteroid (17 beta) dehydrogenase 6 antibody; Hydroxysteroid (17 beta) dehydrogenase 6 homolog (mouse) antibody; Hydroxysteroid 17 beta dehydrogenase 6 antibody; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase antibody; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase antibody; Oxidative 3 alpha hydroxysteroid dehydrogenase antibody; Oxidative 3-alpha hydroxysteroid dehydrogenase antibody; Oxidoreductase antibody; Retinol dehydrogenase antibody; RODH antibody; SDR9C6 antibody; Short chain dehydrogenase/reductase family 9C, member 6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human HSD17B6
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
  • 基因功能参考文献：
    1. No significant difference was found in genotype or allele distributions of the polymorphisms rs12529 of HSD17B5 and rs898611 of HSD17B6 between patients with PCOS and controls. PMID: 25422294
    2. the CYP11A1, CYP17A1, HSD3B2, SRD5A2, and HSD17B6 mRNA levels in metastases were significantly lower. PMID: 24244276
    3. data suggest that there is no association of HSD17B6 and HSD17B5 variants with the occurrence of polycystic ovary syndrome in the Chinese population PMID: 21039282
    4. 17beta-hydroxysteroid dehydrogenase type 6 (17betaHSD6) converts the androgen DHT to the estrogen 3beta-Adiol, and this leads to activation of the ERbeta reporter. PMID: 22114194
    5. These data suggest that polymorphisms in the HSD17B6 gene are associated with PCOS and key clinical phenotypes of the disorder. PMID: 17070195
    6. RoDH enzymes are expressed in tissues that have microsomal 3alpha-hydroxysteroid dehydrogenase/epimerase activities PMID: 17289849
    7. These replication data suggest a role for HSD17B6 in polycystic ovary syndrome PMID: 19837928

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  • 亚细胞定位：
    Microsome membrane; Peripheral membrane protein; Lumenal side. Early endosome membrane; Peripheral membrane protein; Lumenal side.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 组织特异性：
    Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosu
  • 数据库链接：

    HGNC: 23316

    OMIM: 606623

    KEGG: hsa:8630

    STRING: 9606.ENSP00000318631

    UniGene: Hs.524513