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GRID2 Antibody

  • 货号：
    CSB-PA008961
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 3T3 cells using GluR-δ2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O43424
  • 基因名：
    GRID2
  • 别名：
    delta-2 antibody; GluD2 antibody; GLUR D2 antibody; GluR delta 2 antibody; GluR delta-2 subunit antibody; GLURD 2 antibody; GLURD2 antibody; Glutamate receptor delta 2 subunit antibody; Glutamate receptor ionotropic antibody; Glutamate receptor ionotropic delta 2 antibody; GRID 2 antibody; Grid2 antibody; GRID2_HUMAN antibody; MGC117022 antibody; MGC117023 antibody; MGC117024 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human GluR-δ2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex.
  • 基因功能参考文献：
    1. Report on a consanguineous family with autosomal recessive childhood onset of cerebellar ataxia and delayed psychomotor development. Using whole exome sequencing we identified a novel homozygous missense variant [c.2128C > T, p.(Arg710Trp)] in GRID2 that segregates with the disease. The missense variant is located in a conserved region encoding the extracellular serine-binding domain of the GluD2 protein. PMID: 29207948
    2. GRID2 gene can be a suppressor in TNF-induced neurodegeneration which may help to understand the main factors leading to autism. PMID: 27019035
    3. Glutamate system genes including have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium. PMID: 26905411
    4. findings suggest a possible role of GRID2 in the susceptibility to develop mevalonate kinase deficiency. GRID2 gene associated with MKD: The rs1450500 SNP was differently distributed in patients with MKD with respect to those with recurrent fever. PMID: 25146332
    5. We demonstrated for the first time GRID2 expression and localization in human and murine retina, providing evidence for a novel functional role of GRID2 in the retina. PMID: 25122145
    6. GRID2 point mutations: cerebellar ataxia is the core phenotype, but with variable severity ranging from very mild adult-onset to congenital-onset linked to both the heterozygous and homozygous state of the variant, and the position of the mutation. PMID: 25841024
    7. GluD2 gating is triggered by type 1 metabotropic glutamate receptors. PMID: 24357660
    8. GRID2 mutations are associated with a recessive syndrome causing cerebellar ataxia and eye movement abnormalities. PMID: 24078737
    9. Tests for gene-environment interaction between these 33 genes and maternal smoking found evidence for interaction with two additional genes: GRID2 and ELAVL2 among European mothers PMID: 23512105
    10. Glutamate receptor delta2 is involved in a common mechanism that restricts the number of synaptic AMPA receptors at parallel fiber synapses in cerebellar Purkinje cells. PMID: 21368048
    11. Thus, phosphorylation of -2T and/or -1S of GluRdelta2 C-terminus by PKA may regulate the binding of GluRdelta2 to its scaffolding protein, Delphilin. PMID: 17027646
    12. The carboxy terminus of transgenic GluRdelta2 conveys the signal(s) necessary for long-term depression induction and motor learning. PMID: 18256267

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  • 相关疾病：
    Spinocerebellar ataxia, autosomal recessive, 18 (SCAR18)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRID2 subfamily
  • 数据库链接：

    HGNC: 4576

    OMIM: 602368

    KEGG: hsa:2895

    STRING: 9606.ENSP00000282020

    UniGene: Hs.162727